Mathematical Modeling of the Physics of Blood Flow along a Constricted Artery during Treatment of Cancer using Hyperthermia

Main Article Content

Annord Mwapinga

Abstract

Abstract


A numerical investigation of a unidirectional unsteady flow of blood and heat transfer through an artery with a stenotic condition during heat therapy has been performed aiming at determining the dynamics of fluid (blood) flow and heat transfer. Blood is treated to obey the Newtonian law of viscosity. The arterial wall is considered to be rigid due to the presence of stenosis. Heat transfer has been studied under the presence of external heat source that is used to raise body temperature during treatment under hyperthermia. The formulated model equations have been solved using finite difference scheme and simulations are done using MATLAB software. Velocity and temperature profiles have been plotted subject to varying some flow parameters such as Reynolds number, Pranditl number, Eckert number and heat the source parameter. Skin friction and Nusselt number have been plotted to see their varying behavior during heat therapy. A validation of this formulation is shown by comparing the current findings with those from the existing literature.

Downloads

Download data is not yet available.

Article Details

Annord Mwapinga. (2024). Mathematical Modeling of the Physics of Blood Flow along a Constricted Artery during Treatment of Cancer using Hyperthermia. Computational Mathematics and Its Applications, 010–017. https://doi.org/10.17352/cma.000006
Research Articles

Copyright (c) 2024 Mwapinga A.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing and protecting the author rights is the central aim and core of the publishing business. Peertechz dedicates itself in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. Peertechz licensing terms are formulated to facilitate reuse of the manuscripts published in journals to take maximum advantage of Open Access publication and for the purpose of disseminating knowledge.

We support 'libre' open access, which defines Open Access in true terms as free of charge online access along with usage rights. The usage rights are granted through the use of specific Creative Commons license.

Peertechz accomplice with- [CC BY 4.0]

Explanation

'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license.

With this license, the authors are allowed that after publishing with Peertechz, they can share their research by posting a free draft copy of their article to any repository or website.
'CC BY' license observance:

License Name

Permission to read and download

Permission to display in a repository

Permission to translate

Commercial uses of manuscript

CC BY 4.0

Yes

Yes

Yes

Yes

The authors please note that Creative Commons license is focused on making creative works available for discovery and reuse. Creative Commons licenses provide an alternative to standard copyrights, allowing authors to specify ways that their works can be used without having to grant permission for each individual request. Others who want to reserve all of their rights under copyright law should not use CC licenses.

Kucharczyk K, Kaczmarek K, Jozefczak A, Slachcinski M, Mackiewicz A, Dams-Kozlowska H. Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres. Mater Sci Eng C Mater Biol Appl. 2021;120:111654. Available from: https://doi.org/10.1016/j.msec.2020.111654

Danewalia S, Singh K. Bioactive glasses and glass–ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives. Mater Today Bio. 2021;10:100100. Available from: http://dx.doi.org/10.1016/j.mtbio.2021.100100

Darvishi V, Navidbakhsh M, Amanpour S. Heat and mass transfer in the hyperthermia cancer treatment by magnetic nanoparticles. Heat Mass Transfer. 2022;58(6):1029-1039. Available from: https://link.springer.com/article/10.1007/s00231-021-03161-3

Ghanmi A, Abbas IA. An analytical study on the fractional transient heating within the skin tissue during the thermal therapy. J Therm Biol. 2019;82:229-233. Available from: https://doi.org/10.1016/j.jtherbio.2019.04.003

Kikumori T, Kobayashi T, Sawaki M, Imai T. Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-her2 immunoliposomes. Breast Cancer Res Treat. 2009;113(3):435-441. Available from: https://doi.org/10.1007/s10549-008-9948-x

Zagar TM, Oleson JR, Vujaskovic Z, Dewhirst MW, Craciunescu OI, Blackwell KL, et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data. Int J Hyperthermia. 2010;26(7):612-617. Available from: https://doi.org/10.3109/02656736.2010.487194

Zain NM, Ismail Z. Numerical solution of magnetohydrodynamics effects on a generalised power law fluid model of blood flow through a bifurcated artery with an overlapping shaped stenosis. PLoS One. 2023;18(2). Available from: https://doi.org/10.3109/02656736.2010.487194

Razavi A, Shirani E, Sadeghi M. Numerical simulation of blood pulsatile flow in a stenosed carotid artery using different rheological models. J Biomech. 2011;44(11):2021-2030. Available from: https://doi.org/10.1016/j.jbiomech.2011.04.023

Majee S, Shit G. Modeling and simulation of blood flow with magnetic nanoparticles as carrier for targeted drug delivery in the stenosed artery. Eur J Mech B Fluids. 2020;83:42-57. Available from: http://dx.doi.org/10.1016/j.euromechflu.2020.04.004

Shahzad H, Wang X, Sarris I, Iqbal K, Hafeez MB, Krawczuk M. Study of non-newtonian biomagnetic blood flow in a stenosed bifurcated artery having elastic walls. Sci Rep. 2021;11(1):23835. Available from: https://doi.org/10.1038/s41598-021-03426-1

Nadeem S, Ali S, Akkurt N, Hamida MBB, Almutairi S, Ghazwani HA, Eldin SM, Khan ZA, Al-Shafay A. Modeling and numerical simulation of non-newtonian arterial blood flow for mild to severe stenosis. Alexandria Eng J. 2023;72:195-211.

Hussain A, Dar MNR, Cheema WK, Tag-eldin EM, Kanwal R. Numerical simulation of unsteady generic newtonian blood flow and heat transfer through discrepant shaped dilatable arterial stenosis. Results Eng. 2023;18:101189. Available from: http://dx.doi.org/10.1016/j.rineng.2023.101189

Mwapinga A. Computational modeling of arterial blood flow in the presence of body exercise. PhD thesis, University of Dar es Salaam, 2012.

Mwapinga A, Mureithi E, Makungu J, Masanja VG. Mhd arterial blood flow and mass transfer under the presence of stenosis, body acceleration and chemical reaction: a case of magnetic therapy. 2020. Available from: http://dx.doi.org/10.22457/jmi.v18a8164

Changdar S, De S. Numerical simulation of nonlinear pulsatile newtonian blood flow through a multiple stenosed artery. Int Sch Res Notices. 2015;2015: Article ID 628605. Available from: https://doi.org/10.1155%2F2015%2F628605

Mwapinga A, Mureithi E, Makungu J, Masanja VG. Non-newtonian heat and mass transfer on mhd blood flow through a stenosed artery in the presence of body exercise and chemical reaction. 2020. Available from: https://scik.org/index.php/cmbn/article/view/4906

Umadevi C, Dhange M, Haritha B, Sudha T. Flow of blood mixed with copper nanoparticles in an inclined overlapping stenosed artery with magnetic field. Case Stud Therm Eng. 2021;25:100947. Available from: https://doi.org/10.1016/j.csite.2021.100947

Kumar D, Satyanarayana B, Kumar R, Kumar S, Deo N. Application of heat source and chemical reaction in mhd blood flow through permeable bifurcated arteries with inclined magnetic field in tumor treatments. Results Appl Math. 2021;10:100151. Available from: https://doi.org/10.1016/j.rinam.2021.100151

Mwapinga A. Mathematical formulation and computation of the dynamics of blood flow, heat and mass transfer during mri scanning. Sci Rep. 2024;14(1):6364. Available from: https://www.nature.com/articles/s41598-024-56844-2

Berger S, Jou LD. Flows in stenotic vessels. Annu Rev Fluid Mech. 2000;32(1):347-382. Available from: https://doi.org/10.1146/annurev.fluid.32.1.347

Sankar D, Lee U. Fdm analysis for mhd flow of a non-newtonian fluid for blood flow in stenosed arteries. J Mech Sci Technol. 2011;25:2573-2581. Available from: https://link.springer.com/article/10.1007/s12206-011-0728-x

Haghighi AR, Kabdool AA, Asl MS, Kiyasatfar M. Numerical investigation of pulsatile blood flow in stenosed artery. Int J Appl Comput Math. 2016;2:649-662. Available from: https://link.springer.com/article/10.1007/s40819-015-0084-0

Isah A, Musa A, Yakubu G, Adamu GT, Mohammed A, Baba A, Kadas S, Mahmood A. The impact of heat source and chemical reaction on mhd blood flow through permeable bifurcated arteries with tilted magnetic field in tumor treatments. Comput Methods Biomech Biomed Engin. 2024;27(5):558-569. Available from: https://doi.org/10.1080/10255842.2023.2190833